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KMID : 0191119920070030189
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Journal of Korean Medical Science
1992 Volume.7 No. 3 p.189 ~ p.192
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Transcription of class II MHC gene by interferon-gamma in FRTL-5 cells
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Lee MS
Lee JO/Kang TW/Lee JH
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Abstract
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The intracellular mechanism by which interferon-gamma induces the expression of class II
major histocompatibility complex (MHC) antigen in nonlymphoid cells is not clear. The effect of recombinant rat interferon-gamma (IFN-gamma), and cycloheximide on the expression of class II MHC gene was studied using the techniques of immunocytochemical staining and northern blot analysis. IFN-gamma induced de novo transcription of class II MHC gene and class II MHC antigen expression on the cell surface. Cycloheximide did not inhibit IFN-gamma-induced class II MHC antigen expression in a dose-dependent manner indicating translational blockade. These results
suggest that IFN-gamma induces class II MHC antigen expression via de novo transcription of class II MHC gene leading to synthesis of new class II MHC molecule.
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KEYWORD
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